pI: 4.7445 |
Length (AA): 653 |
MW (Da): 74582 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 651 | 3wst (A) | 1 | 641 | 42.00 | 0 | 1 | 1.51334 | -0.37 |
61 | 132 | 2b3t (A) | 108 | 180 | 18.00 | 0 | 0.29 | 0.25706 | 0.08 |
65 | 173 | 3lec (A) | 21 | 121 | 18.00 | 0 | 0.63 | 0.327722 | -0.58 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130603)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G16570 | protein arginine N-methyltransferase 7 |
Brugia malayi | Bm1_54220 | Protein arginine N-methyltransferase |
Caenorhabditis elegans | CELE_W06D4.4 | Protein PRMT-7 |
Drosophila melanogaster | Dmel_CG9882 | Arginine methyltransferase 7 |
Echinococcus granulosus | EgrG_000427200 | protein arginine N methyltransferase 7 |
Echinococcus multilocularis | EmuJ_000427200 | protein arginine N methyltransferase 7 |
Homo sapiens | ENSG00000132600 | protein arginine methyltransferase 7 |
Leishmania braziliensis | LbrM.06.0840 | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 |
Leishmania donovani | LdBPK_060900.1 | protein arginine n-methyltransferase 7 |
Leishmania infantum | LinJ.06.0900 | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 |
Leishmania major | LmjF.06.0870 | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 |
Leishmania mexicana | LmxM.06.0870 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05876 | protein arginine N-methyltransferase |
Mus musculus | 214572 | protein arginine N-methyltransferase 7 |
Oryza sativa | 4339860 | Os06g0105500 |
Schistosoma japonicum | Sjp_0112410 | ko:K00599 PRMT7, LOC479677; protein arginine methyltransferase 7 [EC:2.1.1.-], putative |
Schistosoma japonicum | Sjp_0095560 | Protein arginine N-methyltransferase 7, putative |
Schistosoma mansoni | Smp_025550 | protein arginine n-methyltransferase |
Schmidtea mediterranea | mk4.002889.01 | Protein arginine N-methyltransferase 7 |
Trypanosoma brucei gambiense | Tbg972.7.6370 | arginine N-methyltransferase, putative |
Trypanosoma brucei | Tb927.7.5490 | protein arginine n-methyltransferase 7 |
Trypanosoma cruzi | TcCLB.510303.310 | protein arginine n-methyltransferase 7 |
Trypanosoma cruzi | TcCLB.509153.100 | arginine N-methyltransferase, type III |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.5490 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.5490 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.5490 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.5490 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | protein arginine methyltransferase 7 | Compounds | References |
3 literature references were collected for this gene.